No praise for folly: genomics will never be useful in arterial thrombosis

Life Will Never Be the Same

It seems appropriate that the Cold Spring Harbor Genome Sequencing and Biology Meeting, which witnessed the creation of the Human Genome Organization (HUGO) in 1988, should this year present three major advances in genomic science: the completion of the ®nished sequence of Drosophila melanogaster; the announcement that 85% of the genome of Homo sapiens is now in draft sequence; and the complete...

Why Computers Will Never Be People

The notion that computers and robots either have a measure of intelligence, or at least will have at some stage, has firmly taken root in Western culture. It has inspired a slew of science fiction novels and films, and one of these, ‘The Matrix’, has attained the status of a modern classic. Moreover, it has powerful advocates in the scientific and philosophical fraternities, the most prominent ...

There Will Never Be Another You.

How Useful Will Functional Proteomics Data Be?

Large-scale protein interaction maps are, with gene expression profiles, among the first examples of data sets generated without specific knowledge on functions of genes. These are technology-driven experiments rather than hypothesis-driven experiments. They are valuable tools for protein function prediction, despite the occurrence of typical artifacts. These approaches are still in their early...

When There Will Never be a Randomized Controlled Trial

There are many unanswered questions about how to manage secondary hyperparathyroidism and associated alterations in mineral metabolism in patients with end-stage renal disease. We provide commentary on an observational study by Komaba et al. that presents interesting new insights into the long-standing controversy related to the impact of parathyroidectomy on survival of hemodialysis patients.